Immune profile – Communicable Diseases Research

Humoral response to COVID-19 vaccination in MS patients on disease modifying therapy: Immune profiles and clinical outcomes

Article

Published on 2022-11-012022-10-05
Journal: Multiple sclerosis and related disorders
[Category] COVID19(2023년), SARS, 바이오마커, 진단, 치료기술,

Distinct Immune Phenotypes and Cytokine Profiles in Children with Differing Severity of COVID-19

Article

Published on 2022-11-012022-11-15
Journal: The Pediatric Infectious Disease Journal
[Category] SARS, 진단, 치료기술,

[키워드] Absolute lymphocyte count activated acute phase acute respiratory syndrome Anti-inflammatory Antibody Response CD3 CD4 CD8 Cell children children with COVID-19 Clinical outcome clinical presentation coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patients cytokine profile decrease dependent on disease severity distress effector memory exhibited groups help HLADR IL-1ra IL-1β immune mechanism Immune phenotype Immune profile increase in Infection Inflammatory Laboratory parameters Mild MIS-C no difference not significantly different Patient pediatric profile prospective cohort study RANTES SARS-CoV-2 IgG SARS-CoV2 sera severe disease severity syndrome T cell T cells tumor necrosis factor-α was performed with COVID-19
[DOI] 10.1097/INF.0000000000003669 PMC 바로가기

SARS-CoV-2 Variant-Specific Infectivity and Immune Profiles Are Detectable in a Humanized Lung Mouse Model

Article

Published on 2022-10-162022-11-15
Journal: Viruses
[Category] COVID19(2023년), SARS, 변종, 치료기술,

Probing SARS-CoV-2-positive plasma to identify potential factors correlating with mild COVID-19 in Ghana, West Africa

Article

Published on 2022-10-032022-11-15
Journal: BMC Medicine
[Category] COVID19(2023년), SARS, 바이오마커,

[키워드] ABO ABO blood grouping ABO blood groups acute respiratory syndrome African anti-SARS-CoV-2 antibody antibodies antibody association Asymptomatic Asymptomatic case Blood Blood Group Clustering comparison Concentration coronavirus coronavirus disease correlations COVID-19 COVID-19 severity cytokine cytokine level decrease discrepancy disease severity Eotaxin Factor genetic background group groups Host identify IL-6 IL-8 immune marker Immune profile immune response individuals Kruskal-Wallis Mann-Whitney U test Mild Multiple Multiplex assay offer participant PCR-confirmed performed phenotype plasma Probing proportion quantification recorded reduced regression analysis significantly Spearman statistically significant symptomatic symptomatic and asymptomatic symptomatic patient tested two-tailed was performed was used West West Africa.
[DOI] 10.1186/s12916-022-02571-2 PMC 바로가기

The next frontier in vaccine design: blending immune correlates of protection into rational vaccine design

Review

Published on 2022-10-012022-10-05
Journal: Current opinion in immunology
[Category] COVID19(2023년), SARS, 변종, 비임상, 진단,

The Kinetics of SARS-CoV-2 Antibody Development Is Associated with Clearance of RNAemia

Article

Published on 2022-08-302022-11-15
Journal: mBio
[Category] COVID19(2023년), SARS, 진단,

[키워드] accelerated antibody baseline binding binding activity binding antibody Characteristics clearance COVID-19 COVID-19 disease COVID-19 disease severity Critical death defined development disease disease severity dissemination effective Evolution examined FcγR feature function highlight humoral humoral immune response IgG IgG3 immune immune clearance immune function Immune profile independent Kinetics Longitudinal data longitudinal data modeling maturation monoclonal Mortality natural infection neutralization outcome persistence persistent persistent SARS-CoV-2 plasma viremia plasma predict progression provide SARS-CoV-2 SARS-CoV-2 replication severe COVID-19 Specificities subunit system serology viral clearance viral replication Viremia viremia.
[DOI] 10.1128/mbio.01577-22 PMC 바로가기

Cellular heterogeneity in disease severity and clinical outcome: Granular understanding of immune response is key

Article

Published on 2022-08-222022-11-16
Journal: Frontiers in Immunology
[Category] 유전자 메커니즘,

Clinical and immunological features associated to the development of a sustained immune humoral response in COVID-19 patients: Results from a cohort study

Article

Published on 2022-08-152022-11-15
Journal: Frontiers in Immunology
[Category] SARS, 진단,

[키워드] abnormality acute infection acute respiratory syndrome anti-cellular antibodies anti-SARS-CoV-2 IgG antibodies antibody Antibody Response Antiviral baseline blood sample CD8 changes in characterized chemokine chemokines clinical cohort study coronavirus coronavirus disease COVID-19 Critical Critical disease Critical illness cytokine Cytokines defined Diagnosis evaluated feature flow cytometry Follow-up humoral humoral immune response Humoral response IgG IgGs IL-13 IL-2 IL-4 immune Immune profile immunological IP-10 key factor lymphocyte Lymphocytes lymphopenia lymphopenia. Measures Neutrophil extracellular trap outcome Patient patients with COVID-19 positive Primary outcome Quantitative recruitment regulatory T cells Research Result SARS-CoV-2 serum serum cytokine Serum level serum titer strongly related sustained T cell T cells the patient variable were assessed
[DOI] 10.3389/fimmu.2022.943563 PMC 바로가기

Multiplexed LNP-mRNA vaccination against pathogenic coronavirus species

병원성 코로나바이러스 종에 대한 다중 LNP-mRNA 백신 접종

Article

Published on 2022-08-022022-09-12
Journal: Cell Reports
[Category] COVID19(2023년), MERS, SARS, 진단,

[키워드] activated adaptive animal models antibody antibody immunity Antibody Response antigen-specific antibody B cell coronavirus Coronavirus vaccines COVID-19 vaccine CP: Immunology cross-reactivity Delta develop Differential gene expression effective feasibility immune immune cells Immune profile immune response immunology increase in induce MERS-CoV mRNA mRNA vaccine multiplexed vaccination multispecies coronavirus vaccine offer pathogenic coronavirus profile responses responses against RNA sequencing SARS-CoV SARS-CoV-2 sequential vaccination significantly single-cell single-cell profiling systems immunology. Transcriptome triplex vaccination vaccination schedule vaccine candidate
[DOI] 10.1016/j.celrep.2022.111160 PMC 바로가기 [Article Type] Article

Defining Clinical and Immunological Predictors of Poor Immune Responses to COVID-19 mRNA Vaccines in Patients with Primary Antibody Deficiency

Article

Published on 2022-08-012022-11-15
Journal: Journal of Clinical Immunology
[Category] COVID19(2023년), SARS, 진단,

[키워드] anti-S IgG antibody association Autoimmunity B-cells baseline CD19 CD4 CD8 Cellular immune response clinical Cohort common common variable immune deficiency coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 mRNA vaccines criteria CVID deficiency develop Diagnosis disease dose expression Frequency HCs humoral IgA IgG IgG deficiency IgG subclasse immune Immune profile immunological characteristics impairment investigated memory Moderna Moderna mRNA vaccine mRNA mRNA vaccine naïve neutralization activity OX40 Patient Pfizer-BioNTech Pfizer-BioNTech mRNA vaccine Poor predicted primary antibody primary antibody deficiency response responses SARS-CoV-2 spike protein Selective IgG subclass deficiency significantly lower Specific Specific antibody deficiency. subset T-cell T-cell Response T-cells vaccination Vaccine vaccine response
[DOI] 10.1007/s10875-022-01296-4 PMC 바로가기